KIF22 in the Prognosis and Immune Biomarking of Pan-Cancer

KIF22, also known as kinesin-like DNA-binding protein (Kid), is a member of the Kinesin superfamily proteins (KIFs). Available evidence indicated that KIF22 was associated with cancer occurrence and development. However, functions underlying mechanisms in carcinogenesis progression remain largely unknown. In this study, we examined expression profile methylation status different cancers, well its associations prognosis, tumor stemness, genomic heterogeneity, immune evasion, infiltration, therapeutic response various types. The results demonstrated level higher tumors than nontumor tissues had strong relationships neoantigen, ESTIMATE, infiltration. showed immunomodulators chemokines. significant relevance drug susceptibility could be useful biomarker for forecasting survival probability reaction. Furthermore, interaction coexpression networks were mainly involved cell division, cycle, DNA repair, antigen processing presentation. used pan-cancer clinical diagnosis, schedule, monitoring.